Anti-Human PDGF-BB (MAB) Monoclonal Antibody
Product Details
Synonyms
Platelet-derived growth factor-BB
Description of Anti-Human PDGF-BB (MAB)
PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet a-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-a and PDGFR-ß. PDGFR-a is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-ß interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-BB is a 24.3 kDa disulfide-linked homodimer of two B chains (218 total amino acids).
Biological Activity
WB: 1:1000; IHC: 1:50-200
Reconstitution
Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.
Shipped at room temperature
Usage: For research use only. Not for use in diagnostic or therapeutic procedures. Not for human use.
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Payment Methods
Paying by bank transfer